Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Cellular senescence / SASP signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Senescence-Activated NAD+ Depletion Rescue | 0.604 | neurodegeneration | Senolytic therapy for age-related neurod |
| Senescence-Induced Lipid Peroxidation Spreading | 0.533 | neurodegeneration | Senolytic therapy for age-related neurod |
| Senescence-Associated Myelin Lipid Remodeling | 0.511 | neurodegeneration | Senolytic therapy for age-related neurod |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759] | Mao P, Wang Z, Duan J, Dong P, Yuan C, L | J Agric Food Chem | 2025 | 1 |
| Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591] | Luo Y, Long M, Wu X, Zeng L | Front Immunol | 2025 | 1 |
| Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283] | Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh | Biochem Pharmacol | 2024 | 1 |
| Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotyp [PMID:38816399] | Gao Z, Guo X, Sun Z, Wu S, Wang Q, Huang | Schizophrenia (Heidelb) | 2024 | 1 |
| Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and De [PMID:38580317] | Velma GR, Krider IS, Alves ETM, Courey J | J Med Chem | 2024 | 1 |
| NAD(+) metabolism, stemness, the immune response, and cancer. [PMID:33384409] | Navas LE, Carnero A | Signal Transduct Target Ther | 2021 | 1 |
| NAD metabolism fuels human and mouse intestinal inflammation. [PMID:28877980] | Gerner RR, Klepsch V, Macheiner S, Arnha | Gut | 2018 | 1 |
| NAD+ and sirtuins in aging and disease. [PMID:24786309] | Imai S, Guarente L | Trends Cell Biol | 2014 | 1 |
| Lipoprotein-associated and secreted phospholipases A₂ in cardiovascular disease: [PMID:21098459] | Mallat Z, Lambeau G, Tedgui A | Circulation | 2010 | 1 |
| Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin prod [PMID:18811942] | Godkin JD, Roberts MP, Elgayyar M, Guan | Reprod Biol Endocrinol | 2008 | 1 |
| Discovery of a glycosylated colchicine derivative as a neuroprotective agent for [PMID:41455281] | ["Jash M", "Gupta S", "Garg S", "Khan J" | European journal of medicinal | 2026 | 0 |
| The NADPH oxidase inhibitor Vas2870 prevents myocyte ferroptosis and improves ca [PMID:41671579] | Wang J, Li CM, Yang B, Tantai RN, Guo HX | British journal of pharmacolog | 2026 | 0 |
| From association to mechanism: Prenatal PFAS Co-exposures induces fetal neural t [PMID:41485332] | Chen Y, Cheng Q, Yang C, Li S, Lin H, Li | Journal of hazardous materials | 2026 | 0 |
| Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses i [PMID:41540498] | Fang F, Xu Q, Shen S, Wang S, Bao C | European journal of medical re | 2026 | 0 |
| Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis [PMID:41822239] | Liu X, Wang C, Han L, Xiao Y, Yu H, Hu Z | Food science & nutrition | 2026 | 0 |
| Arachidonic acid analog AACOCF3 suppresses cPLA2-negative NSCLC cell proliferati [PMID:41544858] | Wang H, Wen Z, Jia Y, Tong X, Wang W et | Biochem Pharmacol | 2026 | 0 |
| Modification of the dermal matrix by senescence associated lipids and its functi [PMID:41690117] | ["Jelleschitz S", "Kremslehner C", "Nage | Redox biology | 2026 | 0 |
| Lactobacillus salivarius li01 alleviates premature ovarian insufficiency via gut [PMID:41951629] | Yao L, Xie S, Zhang S, Ba F, Jing H et a | NPJ Sci Food | 2026 | 0 |
| Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporo [PMID:41016294] | ["Hu L", "Luo M", "Zhu X", "Wang Z", "Ya | Phytomedicine : international | 2025 | 0 |
| Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614] | ["Jin H", "Xue B", "Chen X", "Ma T", "Ma | Environmental pollution (Barki | 2025 | 0 |